Canine Leishmania (LSH Ab) Test

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Introduction

The Canine Leishmania (LSH) Antibody Rapid Test is a highly sensitive and specific test for the detection of the LSH Ab in canine serum. The test delivers speed, simplicity and Test quality at a price point significantly lower than other brands.

Leishmania spp is a parasite that causes leishmaniasis and is vectored by a sandfly of the genus Lutzomyia in the Old World and by sandflies of the genus Lutzomyia in the New World. The main hosts of Leishmania are vertebrates, and common infections include hoofed rabbits, rodents, canids, and humans. Cases of leishmaniasis have been reported in 88 countries worldwide, with 12 million people infected.

Endemic in China is Leishmania donovani, which causes black fever and is also known as the black fever parasite.

The pathogenic mechanism flagellar-free bodies multiply in macrophages, causing massive destruction and hyperplasia of macrophages, which are mainly found in the spleen, liver, lymph nodes, bone marrow and other organs. Plasma cells also proliferate heavily. Cell proliferation is the underlying cause of splenomegaly, hepatomegaly, and lymph node enlargement, with splenomegaly being the most common and the predominant sign of black fever, occurring in more than 95% of cases. In the later stages, they become hardened by the proliferation of reticular fibrous tissue. [1]

Anemia is another important symptom of black fever, with a decrease in red blood cells, white blood cells and platelets in the blood, i.e., a decrease in complete blood picture, due to hypersplenism and massive destruction of blood cells in the spleen. In addition, immune hemolysis is also an important cause of anemia. Experiments have shown that Leishmania antigens are attached to the surface of the patient's erythrocytes, and in addition, one to two of the metabolites of Leishmania donovani are identical to human erythrocyte antigens, so that the anti-leishmanial antibodies produced by the body may bind directly to the erythrocyte membrane and destroy the erythrocytes with the participation of complement, causing anemia. [1]

The patient has a significant decrease in albumin and an increase in globulin in plasma. Due to liver damage, albumin synthesis is reduced and albumin excreted via urine is increased. The presence of urinary protein and hematuria may be related to the occurrence of glomerular amyloidosis and the deposition of immune complexes in the glomeruli of the patient. This, combined with a large proliferation of plasma cells that increases the amount of globulin, eventually leads to an inversion of the ratio of albumin to globulin.

Parameter

Product Name LSH Ab test cassette
Brand Name Testsealabs
Place of Origin Hangzhou Zhejiang, China
Size 3.0mm/4.0mm
Format Cassette
Specimen Serum
Accuracy Over 99%
Certificate ISO
Read Time 10min
Warranty Room temperature 24 months
OEM Available
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